[3-(3-pyridinyl)phenyl]Boronic acid is an organic boron compound with the chemical formula C11H10BNO2. The following is a description of its nature, use, preparation and safety information:
1. nature:
-Appearance: Colorless solid
-Solubility: Soluble in common organic solvents such as ethanol, dichloromethane
-Melting point: about 200-205°C
2. use:
- [3-(3-pyridinyl)phenyl]Boronic acid can be used as a reagent and intermediate in organic synthesis.
-It can be used to catalyze cross-coupling reactions, such as Suzuki coupling reactions, to construct carbon-carbon bonds.
-In drug research and preparation, this compound can be used as an important intermediate for the synthesis of potential drug molecules.
3. Preparation method:
- [3-(3-pyridinyl)phenyl]Boronic acid can be obtained by reacting 3-pyridylboronic acid with 4-(trimethylsilyl) benzene bromide.
4. Safety Information:
- [3-(3-pyridinyl)phenyl]Boronic acid has low toxicity, but it still needs to be used carefully.
-During operation, it is recommended to wear appropriate protective gloves and glasses to avoid direct contact with skin and eyes.
-operation should be away from the source of fire, to avoid the generation of toxic gases.
-For storage, the compound should be placed in a sealed container and stored in a cool, dry place, away from oxidants and acids.